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A breakthrough study published in Nature discovered that a "gain-of-function" mutation in the miR-140 gene leads to a severe, novel autosomal dominant human skeletal dysplasia. 🔬 Function in Cancer and Therapeutics

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In many malignancies—including breast, lung, prostate, and gastrointestinal cancers—miR-140 is significantly downregulated. It typically acts as a tumor suppressor by inhibiting cell proliferation, invasion, and metastasis while encouraging cell death (apoptosis).

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Research from Genes & Development highlights that miR-140 protects against osteoarthritis. It does this by regulating specific genes like ADAMTS5 , which is responsible for breaking down the cartilage matrix.

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