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23484.rar

: Discuss the potential for developing a new class of antihypertensives that specifically target the oxidative state of the cardiovascular system.

: Use of C57BL/6 mice and specialized Cys42Ser KI (knock-in) mice that are resistant to PKG oxidative activation. 23484.rar

The reference appears to be associated with supporting data or supplemental materials for a significant cardiovascular research study titled "Proof of Principle for a Novel Class of Antihypertensives That Target the Oxidative Activation of Protein Kinase G Iα," published by Burgoyne et al. in journals like Science and ResearchGate . : Discuss the potential for developing a new

: Evidence that oxidant-induced PKG Iα disulfide formation occurs in vivo during hypertension. 23484.rar