Specific recurrent fusions validated included BCR-ABL, CCDC6-RET, and PML-RARA.
9,624 tumor samples from TCGA, investigating degron loss (a mechanism that stabilizes proteins, encouraging cancer growth). Key Findings:
This research suggests that degron loss is a general mechanism in tumorigenesis, similar to promoter swapping, as shown in the study's PDF document .
Genetic fusions favor tumorigenesis through degron loss in oncogenes