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House spends much of the episode ignoring the patient to target , a former classmate who got House expelled from Johns Hopkins for cheating years prior.

: House successfully ruins Weber’s clinical trials but remains emotionally isolated, ending the episode by hiring a prostitute for further "distraction".

: House eventually notices nicotine stains on the boy’s fingers and a circular burn on his wrist. He deduces Adam was using off-market antidepressants to quit smoking, which caused a Serotonin Syndrome (serotonin storm). The B-Plot: House’s Revenge

: To discredit Weber’s new migraine medication, House induces a migraine in himself and uses the drug to prove it is ineffective.

: Beyond the burns, Adam experiences inexplicable tachycardia, low potassium, and neurological issues—including a bizarre, sedated orgasm in a hyperbaric chamber.

: The episode's title reflects House using the rivalry with Weber and the intense pain of his self-experimentation to avoid dealing with his emotional pain regarding Stacy.

: Standard diagnostic tools like MRIs or EKGs cannot be used because the patient lacks intact skin for electrode attachment.