The mutation leads to continuous activation of the Gsα protein, increasing cAMP levels.
Symptoms vary widely based on the location and extent of the lesions: Fibrous Dysplasia - StatPearls - NCBI Bookshelf fibrous dysplasia of bone
Fibrous dysplasia is categorized by how many bones it affects: The mutation leads to continuous activation of the
The condition stems from a in the GNAS gene . This mutation is not inherited from parents but occurs spontaneously during early embryonic development. fibrous dysplasia of bone