Downloading ISOs from the internet can be risky. Many sites contain malware or intrusive ads. If you choose to download, community-vetted sources like Vimm's Lair are often cited for safety, though download speeds are generally slower.
The most stable software for running PS2 games.
Guitar Hero - Where to download GH hack roms for PS2? - Facebook
If you primarily want the gameplay experience without the hassle of emulation, many players recommend Clone Hero . It is a free, fan-made PC game that allows you to import the entire setlist from Guitar Hero 1 and play with modern peripheral support.
This is the digital disc image of the game. If you own the physical disc, you can create your own ISO by ripping it with a computer disc drive. How to Set Up and Play