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Prolonged activity leads to hyperthermia, lactic acidosis, and eventually, autonomic instability and multiorgan failure. 3. Clinical Classification SE is broadly categorized into two types: Status Epilepticus: A Clinical Perspective
NMDA and AMPA receptors are trafficked to the synaptic membrane, creating a state of self-sustaining excitatory toxicity. This is for informational purposes only
Status Epilepticus: A Clinical Perspective Status Epilepticus (SE) is a critical neurological emergency characterized by prolonged seizure activity or recurrent seizures without a return to baseline consciousness. This paper explores the evolving definitions of SE, its pathophysiological mechanisms, and current clinical management strategies. With a focus on the "time is brain" paradigm, we examine the transition from early SE to refractory and super-refractory stages, highlighting the importance of rapid intervention to prevent permanent neuronal damage and systemic complications. 1. Introduction Learn more Prolonged activity leads to hyperthermia, lactic
Airway, breathing, circulation (ABC) and blood glucose check.
Benzodiazepines are the first line. Intramuscular Midazolam , Intravenous Lorazepam , or Intravenous Diazepam are standard.
If seizures persist, non-sedative anti-seizure medications (ASMs) such as Levetiracetam , Fosphenytoin , or Valproate are administered.