The anthology features several standalone stories directed by different filmmakers:

After facing difficult questions from their spouses, the two decide to fly to Las Vegas for a week to "let loose" without consequences.

A man must frantically hide evidence of his lover's presence when his family unexpectedly returns home early.

A group of men attend an "Adulterers Anonymous" support group to discuss their addiction to cheating.

Rather than one linear narrative, the film follows two primary characters, Fred (played by Jean Dujardin) and Greg (played by Gilles Lellouche), who serve as the recurring "serial cheaters".