One of Ambrose's most notable discoveries was Marc Jacobs. In the late 1980s, Jacobs was a young, up-and-coming designer struggling to make a name for himself. Ambrose, impressed by his designs and vision, gave Jacobs his first major break by featuring his collection at Bloomingdale's. This exposure helped Jacobs gain recognition and eventually led to his appointment as creative director at Louis Vuitton in 1997.
In recent years, Ambrose's influence has been recognized by the fashion industry. In 2019, she was awarded the prestigious CFDA (Council of Fashion Designers of America) Lifetime Achievement Award, a testament to her enduring impact on the fashion world.
Ambrose also played a crucial role in launching the career of Anna Sui. In the early 1990s, Sui was a struggling designer trying to make a name for herself in the competitive fashion industry. Ambrose, recognizing Sui's talent and unique aesthetic, began featuring Sui's designs at Bloomingdale's. This exposure helped Sui gain recognition and eventually led to her becoming one of the most respected and beloved designers of her generation.