Who Classification Of Skin Tumours -

: The classification reaffirms the 9-pathway model for melanoma, which classifies lesions based on sun exposure (UV damage), anatomical site (e.g., acral, mucosal), and specific molecular drivers.

: Each tumour entry includes clear "essential" diagnostic features and "desirable" criteria to improve diagnostic reliability worldwide. Major Clinical Updates by Category 1. Melanocytic Neoplasms WHO Classification of Skin Tumours

: "Primary cutaneous NUT (Nuclear protein in testis) carcinoma" is included as a new provisional entity. 4. Adnexal & Soft Tissue Tumours : The classification reaffirms the 9-pathway model for

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: The term "variant" is now reserved strictly for genetic alterations in DNA sequences, rather than being used to describe morphological subtypes.

: This term is now used for "intermediate" lesions that exhibit borderline biological behavior but have specific molecular signatures (e.g., BAP1 inactivation or WNT pathway alterations).