Izzie Stevens begins her first round of aggressive chemotherapy. Despite her illness, she remains fixated on planning a lavish wedding for Meredith and Derek.
In the episode " Sweet Surrender " (Season 5, Episode 20), a major feature is the medical case of Jessica Smithson , a six-year-old girl with terminal Tay-Sachs disease. Key Features of the Episode:
Callie’s father visits the hospital, leading to a difficult introduction to Arizona Robbins after he discovers Callie's new relationship.
Detailed episode guides and cast lists can be found on the Grey's Anatomy Universe Wiki and IMDb . "Grey's Anatomy" Sweet Surrender (TV Episode 2009) - IMDb
Lexie Grey deals with the tension between Mark and Derek by stress eating throughout the hospital.